This comprehensive article explores the most common causes of failure in mergers and acquisitions (M&A) and provides actionable mitigation strategies for each. By examining issues such as poor strategic rationale, misaligned expectations, cultural misalignment, inadequate due diligence, and more, the article offers a deep understanding of the challenges that can arise during M&A transactions. The outlined mitigation strategies provide practical guidance for companies seeking to minimize risks, optimize integration, and ensure the long-term success of their M&A endeavors. A must-read for executives, decision-makers, and business professionals involved in the M&A process.